不同强度经皮穴位电刺激对胸腔镜手术患者术后免疫功能的影响

目的观察不同强度经皮穴位电刺激(TEAS)对胸腔镜手术患者术后免疫功能的影响。方法将68例行胸腔镜手术治疗的患者按住院先后顺序采取随机数字表法分为低强度TEAS组、中强度TEAS组、高强度TEAS组和电针组,每组17例。4组术后在镇痛泵治疗的基础上,给予不同强度的TEAS或电针治疗。观察4组患者治疗前后T淋巴细胞亚群、自然杀伤细胞(NK细胞)和血清免疫球蛋白水平。结果4组术后CD3﹢和CD4﹢T淋巴细胞、NK细胞、血清IgM、血清IgG的水平均较术前降低(P<0.05);术后48 h低强度TEAS组和高强度TEAS组的CD3﹢和CD4﹢T淋巴细胞、NK细胞、血清IgM的水平均低于电针组(P<0.05);中强度TEAS组和电针组比较差异无统计学意义(P>0.05)。4组术后CD8﹢T淋巴细胞、CD4﹢/CD8﹢以及血清IgG水平组间比较,差异无统计学意义(P>0.05)。结论中强度TEAS能够有效改善胸腔镜手术后患者的免疫功能。     

养气调血护理法对产后缺乳的临床疗效观察

目的:研究探索养气调血护理法对产后缺乳的临床疗效。方法:将符合纳入标准的120例产后缺乳的剖宫产产妇随机分为实验组(予穴位按摩联合常规护理)和对照组(常规护理),每组60例。观察对比患者的乳房充盈度评分、乳汁粘稠度、乳汁淤积程度。结果:实验组在乳房充盈度评分、泌乳量评分、乳汁瘀积程度、乳汁粘稠度与对照组相比,差异均有统计学意义(P<0.05)。结论:穴位按摩这种养气调血护理的方法对产后缺乳有一定的疗效,值得临床推广,机制有待进一步探讨。     

基于红外热成像技术的膝骨性关节炎患者穴位体表温度规律研究＊

目的 观察膝骨性关节炎患者穴位体表温度分布规律。方法 以256例膝骨性关节炎患者和256例健康受试者为观察对象。使用Fotric 226红外热像仪检测患者和健康受试者腧穴的温度值，每名患者每周固定时间检测1次，共检测4次，健康人检测1次，比较患者组与健康受试者组穴位温度值的差异，比较不同时间点不同部位、经脉温度值的差异。结果 膝骨性关节炎患者血海穴、鹤顶穴、梁丘穴、曲泉穴、内膝眼穴、犊鼻穴、委阳穴、阴陵泉穴、膝关穴、阳陵泉穴、大杼穴、悬钟穴、足三里穴、命门穴、腰阳关穴温度值高于健康受试者（P < 0.05）；患者组胃经的4次皮温均较高（P < 0.05），腰背部的4次皮温均较高（P < 0.05）；KOA相关腧穴4次温度值变化趋势不显著（P > 0.05）。结论 膝关节骨性关节炎患者部分腧穴皮温升高；膝骨性关节炎患者的穴位升温现象具有规律性，与经络、部位相关；膝关节骨性关节炎相关穴位升温效应具有稳定性。     

睾丸及附睾炎性病变体表牵涉痛与穴位敏化形成的联系

目的:观察睾丸及附睾炎性病变患者体表牵涉痛分布区与治疗该类疾病相关穴位的关系,通过动物实验进一步对比相关内脏器官体表敏化区与穴位的关系。方法:临床研究部分将93例睾丸、附睾炎患者临床体查确定的体表痛敏点进行总结分析,将其分布部位与临床治疗该类疾病常用穴位进行对比;动物实验部分观察雄性SD睾丸炎模型大鼠(n=8)、对照组(n=3)注射伊文思蓝(Evans Blue)后体表渗出点,与临床痛敏点和相关穴位对比。结果:临床观察93例睾丸、附睾炎患者体表痛敏点大多分布在下腹部及下肢内侧,腰部及会阴部也有部分分布,痛敏点分布范围与大部分治疗该类疾病常用穴位所处位置在同一区域,并有部分重叠;动物实验观察到体表Evans Blue渗出点与临床痛敏点分布情况高度相似。结论:睾丸、附睾炎性病变引发的体表痛敏点多数与治疗该类疾病的相关穴位所处位置重叠或邻近,提示这些疾病状态下的体表敏化点可能是穴位形成的主要原因。     

西药联合穴位贴敷中西医结合治疗复治肺结核疗效观察

目的评价西药联合穴位贴敷中西医结合治疗复治肺结核的临床疗效。方法选择本院2017年1月～2018年1月收治的60例复治肺结核患者进行分组研究,全部患者根据治疗方法不同随机分为两组,每组各30例。两组均采取西药进行治疗,采用2HRZE/6HRZ标准化疗方案,实验组同时联合穴位贴敷中西医结合进行治疗,治疗后对比分析两组病灶吸收情况及两组临床症状改善情况。结果实验组病灶恶化9例,其病灶显著吸收率达50.0%,总有效率达70.0%,对照组病灶恶化6例,不变5例,其病灶显著吸收率达33.3%,总有效率达63.3%,两组病灶吸收总有效率组间比较,差异具有显著性(P0.05);实验组的疗效指数治疗6个月后显著高于对照组,组间比较,差异具有显著性(P0.05)。结论西药联合穴位贴敷中西医结合治疗复治肺结核疗效确切,可以显著促进病灶吸收,改善临床症状,安全性好,且还可以扶助人体正气,提高机体免疫力,调节全身状态,以达到治疗目的,是治疗复治肺结核的有效方法之一,值得临床广泛推广和应用。     

参麦注射液联合米力农治疗难治性心力衰竭疗效观察

目的探讨参麦注射液联合米力农治疗难治性心力衰竭的临床效果。方法选择难治性心力衰竭患者92例,依据随机数字的方法分为对照组46例和观察组46例,患者入院后均常规治疗,对照组给予米利农治疗,观察组在对照组治疗方法基础上给予参麦注射液。对两组治疗前后的心型脂肪酸结合蛋白(H-FABP),血浆心肌肌钙蛋白Ⅰ(cTnⅠ),氨基末端B型钠尿肽原(NT-proBNP),心率(HR),左心室射血分数(LVEF),每搏输出量(SV)进行对比。对两组的临床治疗效果进行对比。对两组治疗过程中的不良反应对比。结果经过治疗后,对照组的H-FABP从(17.23±3.51)ng/L降低到(15.11±3.12)ng/L,NT-proBNP从(8.13±2.32)μg/L降低到(6.51±1.45)μg/L,cTnⅠ从(31.25±5.01)ng/L降低到(23.81±4.25)ng/L,观察组的H-FABP从(16.97±3.78)ng/L降低到(9.91±3.01)ng/L,NT-proBNP从(8.21±1.98)μg/L降低到(4.13±1.34)μg/L,cTnⅠ从(32.07±5.23)ng/L降低到(18.81±5.12)ng/L,观察组的变化幅度大于对照组,数据差异均具有统计学意义(t=8.135,8.176,5.096,P<0.05),经过治疗后,对照组的HR从(135.26±10.51)次/min降低到(103.81±9.81)次/min,LVEF从(32.41±5.41)%升高到(38.31±4.87)%,SV从(37.91±2.71)mL升高到(43.23±3.47)mL,观察组的HR从(134.81±11.28)次/min降低到(95.31±9.97)次/min,LVEF从(31.87±5.37)%升高到(43.21±4.25)%,SV从(38.11±3.13)mL升高到(50.91±3.68)mL,观察组的变化幅度大于对照组,数据差异均具有统计学意义(t=4.122,-5.142,-10.298,P<0.05),观察组的治疗效果优于对照组,数据差异具有统计学意义(z=-4.994,P<0.05),两组的恶心[4.35%(2/46)VS. 2.17%(1/46)],血压低[6.52%(3/46)VS. 4.35%(2/46)],头晕[8.70%(4/46)VS. 13.04%(6/46)],乏力[15.22%(7/46)VS. 8.70%(4/46)],呕吐[4.35%(2/46)VS. 6.52%(3/46)],室性早搏[2.17%(1/46)VS. 4.35%(2/46)],发生率数据差异均不具有统计学意义(χ^2=0.000,0.000,0.449,0.929,0.000,0.000,P>0.05)。结论利用参麦注射液联合米力农治疗难治性心力衰竭,可以改善心肌功能,提升治疗效果,安全性良好。     

A critical assessment on the role of sentinel node mapping in endometrial cancer

Endometrial cancer is the most common gynecologic malignancy in the developed countries. Although the high incidence of this occurrence no consensus, about the role of retroperitoneal staging, still exists. Growing evidence support the safety and efficacy of sentinel lymph node mapping. This technique is emerging as a new standard for endometrial cancer staging procedures. In the present paper, we discuss the role of sentinel lymph node mapping in endometrial cancer, highlighting the most controversies features.     

Comparison of Protective Effects of Safflor Injection and Extract of Ginkgo Biloba on Lung Ischemia/Reperfusion Injury in Rabbits

Objective:To observe the protective effects of safflor Injection(SI) and extract of Ginkgo biloba(EGB) on lung ischemia-reperfusion injury(LIRI) and investigate its mechanism.Methods:In vivo rabbit model of LIRI was reconstructed.Forty rabbits were randomly and equally divided into four groups:sham-operation group(sham group),ischemia-reperfusion group(model group),ischemia-reperfusion plus SI group(safflor group) and ischemia-reperfusion plus EGB injection group(EGB group).Malondialdehyde(MDA) content,superoxide dismutase(SOD) and xanthine oxidase(XO) activity in serum were measured.The wet/dry weight ratio(W/D) of the lung tissue and activity of myeloperoxidase(MPO) were also tested.Ultrastructure change of the lung tissue was observed by the electron microscope.The expression of intercellular adhesion molecule-1(ICAM-1) was measured by immunohistochemistry(IHC).Results:In the model group,MDA and XO increased and SOD decreased in serum compared with the sham group(P<0.01).The values of W/D,MPO and ICAM-1 of the model group were higher than those of the sham group(P<0.01),but those of the safflor group and EGB group were significantly lower than those of the model group(P<0.01).The IHC demonstrated that ICAM-1 expression in lung tissue of the model group was significantly higher than those of the safflor group(P<0.01).Compared with safflor group,in the EGB group MDA,XO,MPO decreased,SOD and ICAM-1expression increased(P<0.05),but the change of W/D was not statistically significant(P>0.05).Conclusions:SI and EGB may attenuate LIRI through antioxidation,inhibition of neutrophil aggregation and down-regulation of ICAM-1expression.But EGB had more effect on the antioxidation,while SI did better on regulating ICAM-1 expression.